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Short answer
Exosomes are tiny vesicles released by cells. Clinic products are usually extracted from the culture media of iPS cells or umbilical cord stem cells and given by infusion or applied to the skin, all in one day. As of September 2026 exosomes are not covered by Japan's Regenerative Medicine Act registration, so ask carefully about source and quality testing.
01
What exosomes are
Exosomes are nanoscale vesicles released by cells. They carry proteins and nucleic acids and are thought to play a role in communication between cells.
Clinic exosome products are usually extracted and concentrated from stem cell culture media and contain no cells. The two common types are iPS cell-derived and umbilical cord stem cell-derived, and manufacturing methods and concentrations vary widely between makers.
Important: as of September 2026, exosome products are not covered by Japan's Regenerative Medicine Act registration. The MHLW has warned clinics about safety and is discussing regulation. With no unified quality standard yet, it is up to you to ask the right questions.
02
Common reasons people ask
Clinical evidence in humans is still building. These are common situations, not promises of results.
Maintenance and recovery
Energy and recovery, usually by infusion.
Skin
Applied with mesotherapy devices, for texture and radiance.
Alongside other treatments
Asked about as a complement to stem cell or PRP treatment.
03
The process
Consultation
Health, history, and current medications are reviewed.
Product check
Confirm the source, manufacturer, and quality documentation.
Infusion or skin application
Completed the same day.
Observation and follow-up
The physician advises whether repeat sessions make sense.
04
Who it suits, and who needs assessment first
Generally suited
- Understand it is a maintenance option with evidence still building
- Willing to ask about source and quality before signing
- Short on time and want a same-day option
Physician assessment needed first
- Pregnancy or breastfeeding
- Active cancer or a history of cancer
- Severe allergies
- Currently receiving other treatment (tell the physician)
05
Reference cost
Exosome costs vary by source, dose, and number of sessions. We confirm a written quote with the clinic before you travel.
Whether tax is included and whether pricing is per session or a package is confirmed in the clinic's written quote. Coordination fees are explained separately.
06
Questions to ask before signing
- 01Which cells are the exosomes from (iPS, umbilical cord, fat)? Which company makes them, and in what facility?
- 02Is there a quality test report (particle count, sterility, endotoxin)?
- 03What dose is used, and by infusion or skin application?
- 04What does the price include, and how many sessions are recommended?
- 05What happens if I feel unwell?
07
Frequently asked questions
How are exosomes different from stem cell therapy?
Stem cell therapy uses living cells that must be collected and cultured, and is registered under the Regenerative Medicine Act. Exosomes are substances released by cells, contain no cells, can be given the same day, and are not currently covered by that registration.
iPS-derived or umbilical cord-derived: which is better?
There is no single answer. What matters is whether the manufacturer, facility, quality testing, and dose are clearly documented.
Are exosomes safe?
There is no unified quality standard yet and limited long-term human data. Check the product source and test report, and tell the physician your history and medications.
How many sessions?
There is no fixed number; the physician advises based on your goal. Confirm the number, intervals, and total cost before signing.
Further reading
- What are exosome IV drips in Japan? Sources, evidence, and compliance
- Marketing lines worth questioning: “policy window period,” “exclusive technology,” “premium experience”
- Don’t let treatment names drive your anti-aging consultation: where aesthetic medicine, health management, and regenerative medicine differ
Where to have it
GINZA YR CLINIC
Ginza YR Clinic offers iPS cell-derived exosome infusions and combined umbilical cord stem cell exosomes; ask for the product documentation at consultation.